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صفحه اصلی
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اولین کنگره بین المللی رویکردهای نوین سبک زندگی، پیشگیری و درمان سرطان
Role of Magnetic Nanoparticles in Early Diagnostic of Cancer by Magnetic Resonance Imaging
نویسندگان :
Samad Hasani (دانشگاه علوم پزشکی تبریز) , Yunus Soleymani (دانشگاه علوم پزشکی تهران)
کلمات کلیدی :
magnetic nanoparticles،cancer biomarkers،sensors،targeted drug delivery،cancer detection
چکیده :
Introduction: Magnetic nanoparticles (MNPs) have been studied for their potential use in cancer detection, screening, and treatment for several decades. Magnetic nanoparticles can be used to detect cancer early and screen for it using magnetic resonance imaging or sensing systems. These sensors are designed to detect specific biomarkers that can be related to the onset or progression of cancer during and after treatment. Magnetic nanoparticles have unique properties that are widely used in cancer therapy as drug delivery agents to target specific locations by manipulating them in vivo using an external magnetic field. The purpose of this review study was to investigate the implications of magnetic nanoparticles in cancer diagnosis, treatment, and drug delivery, as well as the prospects for future development and challenges Methods: The keywords of “magnetic nanoparticles”, “cancer biomarkers”, “sensors”, “targeted drug delivery”, and “cancer detection” were entered into scientific databases of Google Scholar, Scopus, PubMed, and Elsevier. About ten fully relevant papers were extracted and reviewed Results: Sensors for diagnosis and monitoring of biomarkers involved in cancer based on MNPs included a variety range of targets such as alpha-fetoprotein, anterior gradient homolog 2, cancer antigen 153, carcinoembryonic antigen, human chorionic gonadotropin hormone, Interleukin 6, human prostate cancer cells, etc. Also, the detection methods included electrochemical, UV-Vis spectroscopy, flow cytometry, fluorescence, piezoelectric, colorimetric, and optical methods. Overall, the majority of the papers have reported that MNPs have significant toxicity, which has led to many restrictions on their biomedical and clinical use. Some papers have suggested surface coating and functionalization of MNPs with different organic and inorganic layers as methods to improve their features and reduce their potential toxicity to human health Conclusions: The use of MNPs for drug-targeted delivery is still in continuous development, and the synthesis of high-performance magnetic drug delivery systems and integration of multifunctional ligands are being continuously investigated. Although considerable efforts have been made in medicine related to the use of MNPs for modern and efficient therapies in cancer, there is still much more to discover before these materials can be safely used to increase life expectancy and prolong cancer patient survival. Until obstacles such as elimination from the body and long-term toxicity are completely overcome, their clinical applications are impossible to achieve
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