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صفحه اصلی
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اولین کنگره بین المللی رویکردهای نوین سبک زندگی، پیشگیری و درمان سرطان
Role of intestinal microbiome in inflammatory-mediated colorectal cancer development
نویسندگان :
Fatemeh Hajighasemi (دانشگاه شاهد Department of Immunology, Faculty of Medicine, Shahed University, Tehran, Iran)
کلمات کلیدی :
Microbiome،Cancer،Inflammation،Colorectal
چکیده :
Background: Gut microbiome has a vital role in immune dysregulation/ inflammation. Colorectal cancer (CRC) is one of most widespread carcinoma. Impact of dysregulated intestinal microbiome on CRC establishment and upregulated inflammatory response at site of several CRCs have been reported. Moreover inflammation has an important role in cancer initiation. In this study, gut microbiome influence on inflammatory-mediated colorectal cancer development has been assessed. Methods: Published articles from years 1970 up to now were reviewed exactly. The key words "microbiome, inflammation, colorectal and cancer" were used. Related papers were studied and abstracted. Results: Intestinal microbiota comprises various microorganisms with immunumodulatory effects. Altered microbial composition, partially controlled by nutrition, could promote carcinogenesis somewhat through inflammatory dysregulation. In healthiness, noticeable inhabitant bacteria are gram- bacteroides and gram+ firmicutes. Variations of normal microbial composition might result in replace of obligate bacteria by dangerous microorganisms (including Helicobacter hepaticus) modify T-cell populations in lamina propria cause inflammatory-mediated CRCs. Upregulation of inflammatory cells in site of many CRCs has been found could disregulate cytokines able of cancer promotion. Interleukin-1 (IL-1) and IL-18 have essential role in defense against polyp development and inflammation-driven CRC. A relationship between Escherichia coli, IL-10 absence in lumen and inflammation-induced CRC has been shown. Enterotoxigenic bacteriodes fragilis promotes colonic tumorigenesis through IL-17 mediated inflammation. Discussion: Gut microbiota has strong effect on intestinal immune system and plays an important role in inflammatory dysregulation leading to CRC development. Adaptation of gut microbiome may be effective in modulation of inflammation which might be a potential therapeutic approach in CRC improvement.
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