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صفحه اصلی
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اولین کنگره بین المللی رویکردهای نوین سبک زندگی، پیشگیری و درمان سرطان
Radioprotective Effects of Vitamin C, Cimetidine, and Famotidine on Lipid Peroxidase and Hepatic Glutathione Levels in Mouse Liver
نویسندگان :
Mana Gholami (Department of Biology, Faculty of science, Science and Research Branch, Islamic Azad University, Tehran, Iran) , Ali Asghar Ahmadi (انستیتو پاستور ایران) , Shima Hajimazdarany (Department of Biology, Faculty of Science, Babol Branch, Islamic Azad University, Babol, Iran) , Reza Najibi (Department of Biotechnology and Plant Breeding, Sari Agricultural Sciences and Natural Resources University (SANRU), Sari, Iran)
کلمات کلیدی :
Radioprotective،Vitamin C،Cimetidine،Famotidine،glutathione،lipid peroxidase
چکیده :
Background: Radiation therapy is one of the most effective therapies used for approximately 60% of the cancer patients. During radiation exposure, overproduction of reactive oxygen species (ROS) disrupts the lipid layer of membrane leads to subsequent peroxide radical formation. Cimetidine and Famotidine are histamine H2 receptor antagonist (H2 blocker), which are known as peptic ulcer drugs showing radioprotective effects. Vitamin C is an effective scavenger of free radicals and ROS, with significant radioprotective effects. Materials and Methods: In this experimental study, male mice (6-8 weeks and 28±3 gr) were randomly divided into 5 groups: control group (without drug and radiation), group receiving radiation only, group receiving drug only, group receiving drug and radiation, and group receiving the combination of drugs along with radiation. Then, the activity of lipid peroxidase and the reduced and oxidized levels of glutathione in their liver were evaluated. Results: By increasing radiation dose, lipid peroxidase and oxidized glutathione activity were increased and the glutathione content was reduced. The findings show that, in drug only group, Vitamin C had better protection than the other two drugs and also, the combination of three drugs had excellent radiation protection. Conclusion: Radiation protection of normal cells in radiotherapy is a valuable necessity. A number of drugs have the ability to protect cells against ionizing radiation through different mechanisms. The obtained results suggest that, Famotidine, Cimetidine and Vitamin C can be radioprotective individually or in combination.
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