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صفحه اصلی
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اولین کنگره بین المللی رویکردهای نوین سبک زندگی، پیشگیری و درمان سرطان
Anticancer Activity of an enzymatic hydrolysate from Chlorella vulgaris on Mouse colon cancer cells
نویسندگان :
Zahra Yghoubzadeh (پژوهشکده اکولوژی دریای خزر) , Reza Safari (پژوهشکده اکولوژی دریای خزر)
کلمات کلیدی :
Peptides،Enzymatic hydrolysate،Anticancer activity،Colon cancer،Chlorella vulgaris
چکیده :
Background :Cancer is one of the major causes of mortality in the globe. A number of drugs were derived from natural sources such as plants and microorganisms against various different types of cancer. Chlorella is a unicellular green alga found in fresh and marine water and is widely used as a food supplement. Chlorella vulgaris protein hydrolysate (CVPH) was tested after being hydrolyzed by pepsin as a gastrointestinal protease. Methods: The cytotoxic effect on the CT-26 cell line was evaluated using the MTT assay. Results :The results of toxicity assays showed that the survival rate of the cells was decreased by increasing the concentrations of the peptides (62.5, 125, 250, 500, and 1000 µg/ml). Peptides of <3 kDa molecular weight had a substantial impact on the viability of murine colon cancer cells with an IC50 value of 435 µg/ml. Conclusions :The results of the present study showed that the Chlorella vulgaris hydrolysates protein obtained showed anti-cancer activities against the murine colon cancer (CT-26) cell line. Legal entity responsible for the study: The authors. Funding: Has not received any funding. Disclosure: All authors have declared no conflicts of interest.
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