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صفحه اصلی
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اولین کنگره بین المللی رویکردهای نوین سبک زندگی، پیشگیری و درمان سرطان
Evaluation of Epstein-Barr virus infection in patients with ocular lymphoma referred to Farabi hospital, Tehran during 2016-2021
نویسندگان :
Fahimeh Asadi amoli (TUMS) , Solaleh Hedayati (tums)
کلمات کلیدی :
cular adnexal lymphoma،Immunohistochemistery،Epstein-Barr virus،Latent membrane protein
چکیده :
Evaluation of Epstein-Barr virus infection in patients with ocular lymphoma referred to Farabi hospital, Tehran during 2016-2021 Abstract Dr. Fahimeh Asadi Amoli , Dr. Solaleh Hedayati Background: Lymphomas are one of most common ocular adnexal tumors. The role of Epstein-Barr virus (EBV) as an etiologic agent in the development of non-Hodgkin lymphoma has been suggested by detection of membrane protein of virus in these tumors. The presence of EBV in tumoral samples is identified by immunohistochemical staining of latent membrane protein-1 (LMP-1). S, the aim of present study is evaluation of EBV infection in patients with ocular adnexal lymphoma referred to Farabi hospital, Tehran during 2016 to 2021. Material and method: In this cross-sectional retrospective study, 40 paraffin blocks corresponding to patients with ocular adnexal lymphoma admitted to Farabi hospital, Tehran during 2016 to 2021 were immunohistochemically stained by EBV-LMP1 antibody. Membreanous and cytoplasmic staining in more than 5% of tumor cells considered as positive staining. Also, data about patients age and gender and histologic subtype of tumors were extracted from patients medical records. Results: The mean of patients age investigated in this study was 61.1 ± 15.82 years and 65% were male. EBV-LMP1 expression was seen in 10 samples (25%). Frequency of this marker in Extra-nodal Marginal zone lymphoma, Diffuse large B cell lymphoma and Small lymphocytic lymphoma was 23.8%, 33.3% and 33.3% respectively. None of Mantle cell lymphoma and T cell lymphoma samples show EBV-LMP1 expression. Frequency of EBV in patients more than 50 years was significantly higher than patients under 50 years (P=0.045). There is no significant relationship between EBV infection with patients gender and tumor histologic subtype. Conclusion: EBV is detectable in one furth of ocular adnexal lymphomas and its frequency is higher in Diffuse large B cell lymphoma and Small lymphocytic lymphoma and also patients more than 50 years. So more study is necessary for evaluation of EBV infection in pathogenesis of ocular adnexal lymphoma. Kay words: Ocular adnexal lymphoma, Epstein-Barr virus, Latent membrane protein, Immunohistochemistery
لیست مقالات
ثمین همایش، سامانه مدیریت کنفرانس ها و جشنواره ها - نگارش 35.4.1
