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صفحه اصلی
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اولین کنگره بین المللی رویکردهای نوین سبک زندگی، پیشگیری و درمان سرطان
اثرات کاسنی و شاه تره بر گرگرفتگی بیماران مبتلا به سرطان پستان در مقایسه با ونلافاکسین: یک کارآزمایی بالینی تصادفی شده
نویسندگان :
هانیه بابایی (دانشگاه علوم پزشکی شهید بهشتی) , غزاله حیدری راد (دانشگاه علوم پزشکی شهید بهشتی)
کلمات کلیدی :
Traditional Medicine،Cancer،Nutrition،Hot Flashes
چکیده :
Effects of Chicory and Fumitory on Hot Flashes of Breast Cancer Survivors Compared to Venlafaxine: A Randomized Clinical Trial Ghazaleh Heydarirad1,Hanieh babaei2 * 1.Assistant Professor, Department of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran 2*.Reasercher, Department of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Introduction Hot flashes as an inevitable bothersome side effect of cancer therapy is an unsolved health problem in breast cancer survivors that can clearly affect quality of life of patients. The aim of this study was to compare the efficacy of distilled of chicory and fumitory as a conventional herbal remedy in Traditional Persian Medicine with venlafaxine on improving of hot flashes in breast cancer patients. Materials and Methods In this randomized clinical trial, participants by block randomization allocated in two groups: those who consumed distillate of chicory and fumitory (DCF), and those who took venlafaxine. The patients in two groups recorded the number and severity of hot flashes in daily diary one week before starting the intervention (baseline week). After that, they started to drink DCF (150 cc twice daily) or venlafaxine (37.5 mg in first week and 75 mg in the next three weeks) for four weeks, and accordingly completed the daily diary. Results 24 patients in DCF group and 17 patients in venlafaxine group completed the study. After four weeks, frequency of hot flashes in DCF group was 30.70% (p-value<0.001), and 40.88% in venlafaxine group (p-value<0.001). Also, DCF could decrease mean score of hot flashes to 41.34% (p-value<0.001), and venlafaxine could decrease to 56.93% (p-value<0.001). There were no significant differences between two groups during the first three weeks of the intervention. However, in the last week of the study, venlafaxine was more effective than DCF. As well, fewer side effects were observed in participants who received DCF. Discussion This study aimed to compare the efficacy of chicory and fumitory, a conventional herbal remedy in Traditional Persian Medicine, with venlafaxine in improving hot flashes in breast cancer patients. The results showed that DCF could improve hot flashes as well as venlafaxine. However, venlafaxine was significantly more effective in managing hot flashes in the last week of the intervention. It should be noted that although venlafaxine was more effective, it was difficult for patients to tolerate it, and a few participants withdrew from the study due to various side effects, especially in the first week of the intervention. Conclusion DCF as well as venlafaxine could improve hot flashes score and frequency in women with breast cancer who were undergoing hormonal therapy. However, in the last week of intervention, venlafaxine was more efficient in improve hot flashes score and frequency.
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