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صفحه اصلی
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اولین کنگره بین المللی رویکردهای نوین سبک زندگی، پیشگیری و درمان سرطان
تاثیر رویکردهای درمانی بر بهبود موکوزیت ناشی از شیمی درمانی: یک مطالعه مروری سیستماتیک در بیماران با پیوند مغز استخوان
نویسندگان :
سمیه حسن پور (Clinical Research Development Unit, Amirkola Children' s Hospital, Babol University of Medical Sciences, Babol, Iran) , لیلا آب پیکر (Clinical Research Development Unit, Amirkola Children' s Hospital, Babol University of Medical Sciences, Babol, Iran) , احمد تمدنی (Non-Communicable Pediatric Disease Research Center, Amirkola Children' s Hospital, Babol University of Medical Sciences, Babol, Iran) , حسن محمودی (Non-Communicable Pediatric Disease Research Center, Amirkola Children' s Hospital, Babol University of Medical Sciences, Babol, Iran) , منیژه امامی (Clinical Research Development Unit, Amirkola Children' s Hospital, Babol University of Medical Sciences, Babol, Iran)
کلمات کلیدی :
Hematopoietic stem cell transplantation،Bone marrow transplantation،Mucositis،Stomatitis
چکیده :
Introduction: Oral mucositis is one of the common and serious side effects of patients undergoing radiotherapy or chemotherapy. Patients who undergo high-dose chemotherapy before bone marrow transplantation will experience severe oral mucositis, which can cause pain, severe nutritional and psychological problems. 20 to 40 percent of patients receiving chemotherapy suffer from this condition. Therefore, this systematic review study was conducted with the aim of the effect of treatment approaches on the improvement of mucositis caused by chemotherapy in patients with bone marrow transplantation. Methods: The present study is a systematic review in which articles published from 2000-2023 were reviewed from Scopus and PubMed databases. The keywords Hematopoietic stem cell transplantation, Stomatitis, Bone marrow transplantation, Oral mucositis were used for the search. Inclusion criteria included clinical trial articles, English articles. Case report articles, conferences and non-pharmacological studies were excluded. Information such as the name of the author, year and place of the study, type of study, sample size, type of bone marrow transplantation, and treatment method were extracted from the selected studies. Results: After the initial review by two authors, 772 articles were selected. Then the selected articles were examined more closely and finally, 22 articles with 1696 samples (857 in the intervention group and 868 in the control group) were evaluated. The most of the studies were related to Italy (4 studies), America (3 studies), Brazil (3 studies) and Iran (2 studies). The age range of people was between 4-90 years. The treatment methods used included: cryotherapy and laser were respectively 6 and 3 studies. In the 6 studies conducted on cryotherapy, the researchers investigated the effect of cryotherapy in 5 studies compared to routine care on mucositis improvement, 4 of which had a significant difference (P<0.05) and one study did not has a significant difference (P>0.05). Compared to the control group, laser therapy had a significant difference in the improvement of mucositis in the studies conducted (P<0.05). Cefozol, sucralfate, and molgramostim and growth factor mouthwashes did not affect the improvement of mucositis compared to the control group. However, polyprezinc gel, amifostine, cefozol and palifermin, saturated calcium solution and concentrated milk protein, chamomile and peppermint herbal mouthwashes were effective. Conclusions: According to the results of the studies, cryotherapy and laser were effective in improving mucositis, it can be used to improve mucositis in bone marrow transplant patients.
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