کنگره بین المللی رویکردهای نوین سبک زندگی، پیشگیری و درمان سرطان

صفحه اصلی / اولین کنگره بین المللی رویکردهای نوین سبک زندگی، پیشگیری و درمان سرطان

شیوع عفونت و ژنوتایپهای ویروس پاپیلومای انسانی در زنان 11 تا 50 ساله در مشهد

نویسندگان :

مریم شاهی (جهاد دانشگاهی خراسان رضوی) , اعظم شفائی (جهاد دانشگاهی خراسان رضوی) , محمد قدسی (جهاد دانشگاهی خراسان رضوی) , محمد علی جهانشاهی (جهاددانشگاهی خراسان رضوی)

کلمات کلیدی :

Human papillomavirus،Cervical cancer،Screening،Genotype

چکیده :

Prevalence of infection and genotypes of human papilloma virus in women aged 11 to 50 in Mashhad Maryam Shahi1, Azam Shafaei1,Mohammad Ghodsi1, Mohammad Ali Jahanshahi2 1. Blood Borne Infections Research Center, Academic Center for Education, Culture and Research (ACECR), Razavi Khorasan Branch, Mashhad, Iran. 2. Clinical Laboratory Diagnostic Center, Academic Center for Education, Culture and Research (ACECR), Razavi Khorasan, Mashhad, Iran. Background: Cervical cancer is the fourth most common cancer affecting women worldwide. Human papillomavirus (HPV) is associated with a large number of cancers and is responsible for practically all cases of cervical carcinoma. Identification the role of HPV as a necessary cause of cervical cancer led to the development of HPV testing. Mashhad populations are about 3 million and this city attracts more than 20 million tourists and pilgrims every year. The aim of this study is to determine the prevalence of HPV virus and its genotypes in women in Mashhad. Methods: This cross-sectional study was carried out on 3224 women aged between 11 and 50 yrs who were referred to the central laboratory of Academic Center for Education, Culture, and Research, Mashhad, Iran, from September 2020 to September 2022. Pregnancy, being in the postpartum period and having no history of sexual activity were considering as exclusion criteria. LBC sample was used for DNA extraction and then HPV test. DNA was extracted using nucleic acid extraction system produced by Bioperfectus, China. The HPV DNA test was performed using a high + low papillomastrip kit (OPERON, Spain). This kit detect 37 High-risk (HR) and Low-risk (LR) HPV subtypes. The results were analyzed with SPSS 22 software. Descriptive tests (prevalence, mean and standard deviation) and chi-square test were used to evaluate the results of the study. A P value less than 0.05 was considered statistically significant. Results: In the present study, 43% of all participants were infected with HPV. The highest percentage of HPV infection was observed in the age of under 20 yrs. With increasing age, we saw a decrease in the prevalence of HPV infection in the studied subjects. We found 36 different genotypes in all participants. The most common genotypes in the present study were LR HPV6 (24.4%), HR HPV16 (18%), HR HPV53 (12.8%), LR HPV42 (10.7%), LR HPV54 (10.3%), HR HPV52 (10.1 %) and LR HPV91 (10%). Conclusions: The results of the present study show that HPV53, HPV54 and HPV91 genotypes have replaced the common genotypes in the past and more studies are needed to investigate the common genotypes to apply vaccination programs to prevent cervical cancer. Also, the high prevalence of HPV in women under 20 years shows the importance of screening programs at younger ages. Legal entity responsible for the study: The authors. Funding: Has not received any funding. Disclosure: All authors have declared no conflicts of interest.

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