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صفحه اصلی
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اولین کنگره بین المللی رویکردهای نوین سبک زندگی، پیشگیری و درمان سرطان
The Interplay between Testicular Cancer and Infertility: A Comprehensive Review
نویسندگان :
Emad Reza (دانشگاه تخصصی فناوری‌های نوین آمل) , Hossein Azizi (دانشگاه تخصصی فناوری‌های نوین آمل)
کلمات کلیدی :
Testicular Tumors،Sertoli Cell Tumor،Leydig Cell Tumor،Infertility،Azoospermia
چکیده :
Testicular Cancer and infertility are two distinct medical conditions that can significantly impact an individual's quality of life. While cancer poses a threat to overall health and survival, infertility can lead to emotional distress and challenges in family planning. This review manuscript aims to explore the intricate relationship between Testicular cancer and infertility, shedding light on the underlying mechanisms, treatment approaches, and the impact on patients' reproductive health. Certain genes, including BRCA1, BRCA2, TP53, RB1, DNA repair genes, and hormone receptor genes, are involved in both cancer and infertility. These genes play various roles in regulating the cell cycle, DNA repair, and hormone signalling. Mutations in these genes can increase the risk of cancer and also lead to fertility issues by disrupting reproductive organ development, hormonal imbalances, and impaired DNA repair. Understanding the interactions and mechanisms of these genes can help identify individuals at risk and develop targeted interventions for both cancer prevention and fertility preservation. By understanding this complex interplay, healthcare professionals can provide comprehensive care and support to individuals affected by both cancer and infertility.
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