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صفحه اصلی
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اولین کنگره بین المللی رویکردهای نوین سبک زندگی، پیشگیری و درمان سرطان
Evaluating clinical and pathological characteristics related to colorectal cancer patients’ survival rate by survival tree analysis
نویسندگان :
Sepideh Arjomand Kermani (دانشگاه علوم پزشکی کرمان) , Sajjadeh Movahedinia (دانشگاه علوم پزشکی کرمان) , Mohammad Reza Baneshi (دانشگاه علوم پزشکی کرمان) , Abbas Bahrampour (دانشگاه علوم پزشکی کرمان)
کلمات کلیدی :
Survival tree،Colorectal cancer،Kerman،pathological characteristics،patient
چکیده :
Nowadays, cancer has become one of the most common causes of death worldwide, and the uncontrolled growth and diversity of cancer cells have been identified as one of the most important causes of cancer death. There is a type of cancer called colorectal cancer (CRC) that occurs in the colon, rectum, or appendix when cells continue to grow and increase uncontrollably. Colorectal cancer is the third most prevalent cancer in the world, and there is a steady increase in its incidence in developing countries. Several factors contribute to the growth of colorectal cancer, including obesity, sedentary lifestyles, red meat consumption, alcohol consumption, and smoking. There are a number of side effects associated with colorectal cancer, and these side effects adversely impact a patient's quality of life and compliance with treatment. Identifying risk factors to treat and prepare patients for colorectal cancer is important and could be helpful. In this study, the data of 821 colorectal cancer patients were obtained from Kerman Population-Based Cancer Registry, Shafa hospital, Afzalipour hospital, and Javad-ol-Aeme clinic in Kerman province. This study determined the relationship between a set of clinical and pathological characteristics of colorectal cancer patients, such as tumor size, total lymph node, primary tumor extension, regional lymph node status, lymph node involvement, tumor stage, lymphovascular invasion, perineural invasion, histological grade, histologic type, and tumor site, gender, and age at the time of diagnosis, and survival time by use of survival tree analysis. Survival tree aims to classify patients with the greatest similarity within groups and the least similarity between groups in terms of survival rate. Several advantages of tree models over regression methods exist, including the ability to reveal high-order interactions between independent variables, the use of surrogate variables to handle missing data, and the provision of an easy visual tool for clinical decision-making. The mean and standard deviation of the age at diagnosis for patients who died and those who survived were 64.7±14.2 and 60.9±14.2 years, respectively. Approximately 35 months have been estimated to be the median survival time after diagnosing this disease. This study found that the following variables are associated with colorectal cancer patients' survival time, such as age at diagnosis, stage, total lymph node, tumor site, and histological grade. There is a low survival rate for individuals whose histological grade is poorly differentiated or undifferentiated, the amount of lymph brought is less than 10, the tumor site is located in the right colon or colon (not specified), their cancer stage is 3 or 4, and their age at diagnosis is greater than 79.5 years. There is a higher survival rate for people who had more than ten total lymph nodes, who were in stage I or II of their disease, and who were over seventy-nine years of age at the time that their disease was identified. The purpose of this study was to propose several variables that would assist physicians in making informed decisions about how to control and treat colorectal cancer by identifying risk factors that affect survival time after diagnosis.
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