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صفحه اصلی
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اولین کنگره بین المللی رویکردهای نوین سبک زندگی، پیشگیری و درمان سرطان
Early detection of lung cancer
نویسندگان :
Fatemeh Abiat (دانشگاه آزاد اسلامی واحد مشهد) , Maryam Donyayi (دانشگاه آزاد اسلامی واحد مشهد) , Hedyeh Anbiaie (دانشگاه آزاد اسلامی واحد مشهد) , Fatemeh Aboutorabzade (دانشگاه آزاد اسلامی واحد مشهد)
کلمات کلیدی :
Early detection،Liquid biopsy،LDCT،Lung cancer
چکیده :
Background: Lung cancer is undoubtedly one of the most serious health issues of the 21 st century. The vast majority of lung cancer patients present with advanced-stage of pathological process that ultimately leads to poor prognosis and a five-year survival rate less than 20%. Thus, to better understand lung cancer, the examination of downstream changes occurring at the level of the protein and metabolites might provide helpful information about the disease. Lung cancer is associated with specific molecular changes in the tumor cell of origin as well as changes in the host that are potentially useful for lung cancer screening. Method: this study was a review study that conducted by using PubMed by using keywords of Lung cancer, Early detection, Screening. Finally, 13 out of 18,567 results up to 2023 were examined in detail. Results: Globally, smoking is identified as the primary cause of lung cancer. The early detection of lung cancer has been a difficult goal to attain for decades. Lung cancer screening criteria has expanded to include: patients age 50-80, >20pkyr smoking history or current smoker, former smoker having quit within 15yrs. Multiple new methodologies incorporating genomics are identifying metabolites and miRNA of lung cancer tumors, offering hope for earlier detection. Early and accurate screening and analysis using cost-effective means are urgently needed to effectively diagnose the disease, improve the survival rate or to reduce mortality and morbidity associated with lung cancer patients. However, genomics remains relatively limited in predicting disease onset, mainly because genomic information does not account for the dynamic environmental influences (phenotype). Sputum cytology is the classic screening method for centrally located early squamous lung cancer. Liquid biopsy could become an alternative and complementary screening approach to chest imaging for early diagnosis of lung cancer. Plasma-based detection of lung cancer DNA methylation may provide a simple cost-effective method for the early detection of lung cancer. However, only 16% of patients were diagnosed when the disease was still restricted to the lungs and even for these, only 57.4% survived 5 years. It is evident that the sooner lung cancer is diagnosed, the better the prognosis for the patient. Conclusions: Naturally, attempts have been made to improve the diagnostic value of potential biomarkers using different combinations (of markers and algorithms), aiming to develop a product that would complement current gold standard diagnostic methods for lung cancer. For lung cancer screening protocols, DNA methylation in plasma/sputum should be used alongside LDCT in large-scale population-based studies to develop novel screening algorithms that decrease the rate of false positives. patients at the highest risk for lung cancer and serve as a viable alternative to molecular and proteomic-based markers for the early detection of lung cancer. Therefore, developing a low-cost, high-throughput metabolomic test will make early-stage lung cancer screening feasible and affordable globally, where survival rates are low, particularly for at-risk populations. Legal entity responsible for the study: the authors Funding: no funding Disclosure: no conflicts of interest Keywords: Early detection; Liquid biopsy; LDCT; Lung cancer
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ثمین همایش، سامانه مدیریت کنفرانس ها و جشنواره ها - نگارش 35.4.1
