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صفحه اصلی
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اولین کنگره بین المللی رویکردهای نوین سبک زندگی، پیشگیری و درمان سرطان
Epidemiology of pediatric cancer: A 12-year study at Shafi’zadeh Amirkola Children's Hospital (2008-2019)
نویسندگان :
Faeze Aghajanpour (مرکز تحقیقات بیماری های غیرواگیر کودکان، دانشگاه علوم پزشکی بابل) , Hasan Mahmoodi (مرکز تحقیقات بیماری های غیرواگیر کودکان، دانشگاه علوم پزشکی بابل) , Ahmad Tamaddoni (دانشگاه علوم پزشکی بابل، واحد توسعه تحقیقات بالینی بیمارستان کودکان امیرکلا) , Fariba Khabiri (دانشگاه علوم پزشکی بابل، واحد توسعه تحقیقات بالینی بیمارستان کودکان امیرکلا) , Fatemeh Almasi (مرکز تحقیقات بیماری های غیرواگیر کودکان، دانشگاه علوم پزشکی بابل)
کلمات کلیدی :
Epidemiology،Child،Neoplasmss،Shafizadeh Amirkola Children' Hospital
چکیده :
Introduction: Cancer is the second leading cause of death in children under 14 years of age, after accidents (1, 2). The World Health Organization (WHO) estimates that the incidence rate of childhood cancer is about 100 per million children (3). The incidence rate of childhood cancer in Iran was 48-112 and 51-144 per million in girls and boys in different geographical areas, respectively (4). In general, lymphohematopoietic malignancies such as lymphoma and lymphoblastic leukemia account for 40%, central nervous system tumors account for about 30%, and embryonal malignancies and sarcomas account for about 10% of childhood cancers. Pediatric cancers differ significantly from adult malignancies in terms of cancer type, distribution, and prognosis (5). There is no information about cancer in children in the north of Iran, therefore the aim of this study was to investigate the epidemiology of cancer in children referred to Shafi’zadeh Amirkola Children's Hospital between 2009 and 2020. Shafi’zadeh Amirkola Children's Hospital is an active center in the north of Iran. Materials and Methods: This cross-sectional study was conducted on all children with cancer referred to Shafi’zadeh Amirkola Children's Hospital from 2009 to 2020. Initially, all referred children were visited by the pediatric hematology and oncology specialists of this educational-therapeutic center. The process of clinical diagnosis (clinical examinations) and paraclinical (special tests, collection of cerebrospinal fluid, biopsy of a suspicious organ, ultrasound, CT scan, etc.) was performed and after final confirmation of cancer, 320 children were enrolled in the study. Patient information including demographic information (age at first visit and at disease diagnosis, sex, date of first visit, and place of residence) and type of cancer, were obtained from patients’ medical records and entered into the questionnaire. The data were analyzed using SPSS 24, and a P value of less than 0.05 was considered significant. Results: Of the 320 patients with various types of malignancy, 200 (62.5%) were male and 120 (37.5%) were female. The age range of the children in the study at the time of diagnosis was from less than one year to 18 years, and their mean age was 4.81±4.538 years. A total of 21 types of cancer were diagnosed in these children, of which acute lymphoid leukemia (ALL), acute myeloid leukemia (AML), and neuroblastoma were the most common in 173 (54.1%), 23 (7.2%), and 17 patients (5.3%), respectively. During the follow-up period of these patients, 64 (20%) patients had died, including 20 (31.25%) patients with ALL. There was no significant relationship between patient sex and type of disease (P value=0.731). The average number of newly admitted patients with cancer was 26.67±8.283 patients per year (Chart 1). An investigation of their places of residence revealed that 60.8% of those referred were from outside the cities of Babol and Amirkola (Table 2). Conclusions: The results of this study showed that the most common type of cancer in children referred to this center was leukemia of the ALL type (54.1%) and that childhood cancer was more common in males than in females.
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